Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses.

Autor: Cumberworth SL; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK., Clark JJ; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK., Kohl A; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK., Donald CL; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK.
Jazyk: angličtina
Zdroj: Cellular microbiology [Cell Microbiol] 2017 May; Vol. 19 (5). Date of Electronic Publication: 2017 Mar 22.
DOI: 10.1111/cmi.12737
Abstrakt: The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease. In order to efficiently establish a productive infection in mammalian cells, flaviviruses have developed key strategies to counteract host immune defences, including the type I interferon response. They employ different mechanisms to control interferon signal transduction and effector pathways, and key research generated over the past couple of decades has uncovered new insights into their abilities to actively decrease interferon antiviral activity. Given the lack of antivirals or prophylactic treatments for many flaviviral infections, it is important to fully understand how these viruses affect cellular processes to influence pathogenesis and disease outcome. This review will discuss the strategies mosquito-borne flaviviruses have evolved to antagonise type I interferon mediated immune responses.
(© 2017 The Authors Cellular Microbiology Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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