| Autor: |
Sîrbu A; Moldova State University, Department of Chemistry, A. Mateevici Street 60, MD-2009, Chisinau, Republic of Moldova., Palamarciuc O; Moldova State University, Department of Chemistry, A. Mateevici Street 60, MD-2009, Chisinau, Republic of Moldova., Babak MV; Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543 Singapore. chmawh@nus.edu.sg phamari@nus.edu.sg., Lim JM; Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543 Singapore. chmawh@nus.edu.sg phamari@nus.edu.sg., Ohui K; Institute of Inorganic Chemistry of the University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria. vladimir.arion@univie.ac.at., Enyedy EA; Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7., H-6720 Szeged, Hungary., Shova S; Petru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda, Nr. 41A, 700487 Iasi, Romania., Darvasiová D; Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, SK-81237 Bratislava, Slovakia., Rapta P; Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, SK-81237 Bratislava, Slovakia., Ang WH; Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543 Singapore. chmawh@nus.edu.sg phamari@nus.edu.sg., Arion VB; Institute of Inorganic Chemistry of the University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria. vladimir.arion@univie.ac.at. |
| Abstrakt: |
A series of water-soluble sodium salts of 3-formyl-4-hydroxybenzenesulfonic acid thiosemicarbazones (or sodium 5-sulfonate-salicylaldehyde thiosemicarbazones) containing different substituents at the terminal nitrogen atom (H, Me, Et, Ph) and their copper(ii) complexes have been prepared and characterised by elemental analysis, spectroscopic techniques (IR, UV-vis, 1 H NMR), ESI mass spectrometry, X-ray crystallography and cyclic voltammetry. The proligands and their copper(ii) complexes exhibit moderate water solubility and good stability in aqueous environment, determined by investigating their proton dissociation and complex formation equilibria. The copper(ii) complexes showed moderate anticancer activity in established human cancer cell lines, while the proligands were devoid of cytotoxicity. The anticancer activity of the copper(ii) complexes correlates with their ability to induce ROS accumulation in cells, consistent with their redox potentials within the biological window, triggering the activation of antioxidation defense mechanisms in response to the ROS insult. These studies pave the way for the investigation of ROS-inducing copper(ii) complexes as prospective antiproliferative agents in cancer chemotherapy. |
