Three dimensional graphene scaffold for cardiac tissue engineering and in-situ electrical recording.

Autor: Ameri SK, Singh PK, D'Angelo R, Stoppel W, Black L, Sonkusale SR
Jazyk: angličtina
Zdroj: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2016 Aug; Vol. 2016, pp. 4201-4203.
DOI: 10.1109/EMBC.2016.7591653
Abstrakt: In this paper, we present a three-dimensional graphene foam made of few layers of CVD grown graphene as a scaffold for growing cardiac cells and recording their electrical activity. Our results show that graphene foam not only provides an excellent extra-cellular matrix (ECM) for the culture of such electrogenic cells but also enables recording of its extracellular electrical activity in-situ. Recording is possible due to graphene's excellent conductivity. In this paper, we present our results on the fabrication of the graphene scaffold and initial studies on the culture of cardiac cell lines such as HL-1 and recording of their real-time electrical activity.
Databáze: MEDLINE