[Decontamination of organophosphorus compounds: Towards new alternatives].

Autor:	Poirier L; Inserm, CNRS, IRD, URMITE, Aix Marseille université, Marseille, France., Jacquet P; Inserm, CNRS, IRD, URMITE, Aix Marseille université, Marseille, France., Elias M; Department of Biochemistry, Molecular Biology and Biophysics & Biotechnology Institute, University of Minnesota, St. Paul, MN 55108, États-Unis., Daudé D; Gene&GreenTK, faculté de médecine, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France. Electronic address: david.daude@gene-greentk.com., Chabrière E; Inserm, CNRS, IRD, URMITE, Aix Marseille université, Marseille, France; Gene&GreenTK, faculté de médecine, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France. Electronic address: eric.chabriere@univ-amu.fr.
Jazyk:	francouzština
Zdroj:	Annales pharmaceutiques francaises [Ann Pharm Fr] 2017 May; Vol. 75 (3), pp. 209-226. Date of Electronic Publication: 2017 Mar 06.
DOI:	10.1016/j.pharma.2017.01.004
Abstrakt:	Organophosphorus coumpounds (OP) are toxic chemicals mainly used for agricultural purpose such as insecticides and were also developed and used as warfare nerve agents. OP are inhibitors of acetylcholinesterase, a key enzyme involved in the regulation of the central nervous system. Chemical, physical and biological approaches have been considered to decontaminate OP. This review summarizes the current and emerging strategies that are investigated to tackle this issue with a special emphasis on enzymatic remediation methods. During the last decade, many studies have been dedicated to the development of biocatalysts for OP removal. Among these, recent reports have pointed out the promising enzyme SsoPox isolated from the archaea Sulfolobus solfataricus. Considering both its intrinsic stability and activity, this hyperthermostable enzyme is highly appealing for the decontamination of OP. (Copyright © 2017 Académie Nationale de Pharmacie. All rights reserved.)
Databáze:	MEDLINE
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