Altered Topological Properties of Brain Networks in Social Anxiety Disorder: A Resting-state Functional MRI Study.

Autor:	Zhu H; Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China., Qiu C; Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China., Meng Y; Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China., Yuan M; Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China., Zhang Y; Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China., Ren Z; Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China., Li Y; Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China., Huang X; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China., Gong Q; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China., Lui S; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.; Radiology Department of the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027 China., Zhang W; Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2017 Mar 07; Vol. 7, pp. 43089. Date of Electronic Publication: 2017 Mar 07.
DOI:	10.1038/srep43089
Abstrakt:	Recent studies involving connectome analysis including graph theory have yielded potential biomarkers for mental disorders. In this study, we aimed to investigate the differences of resting-state network between patients with social anxiety disorder (SAD) and healthy controls (HCs), as well as to distinguish between individual subjects using topological properties. In total, 42 SAD patients and the same number of HCs underwent resting functional MRI, and the topological organization of the whole-brain functional network was calculated using graph theory. Compared with the controls, the patients showed a decrease in 49 positive connections. In the topological analysis, the patients showed an increase in the area under the curve (AUC) of the global shortest path length of the network (L p ) and a decrease in the AUC of the global clustering coefficient of the network (C p ). Furthermore, the AUCs of L p and C p were used to effectively discriminate the individual SAD patients from the HCs with high accuracy. This study revealed that the neural networks of the SAD patients showed changes in topological characteristics, and these changes were prominent not only in both groups but also at the individual level. This study provides a new perspective for the identification of patients with SAD.
Databáze:	MEDLINE
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