Lack of association between Toxoplasma gondii exposure and depression in pregnant women: a case-control study.

Autor:	Alvarado-Esquivel C; Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, 34000, Durango, Dgo, Mexico. alvaradocosme@yahoo.com.; Laboratorio de Investigación Biomédica, Facultad de Medicina y Nutrición, Avenida Universidad S/N, 34000, Durango, Dgo, Mexico. alvaradocosme@yahoo.com., Martínez-Martínez AL; Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, 34000, Durango, Dgo, Mexico., Sánchez-Anguiano LF; Institute for Scientific Research 'Dr. Roberto Rivera Damm', Juárez University of Durango State, Avenida Universidad S/N, 34000, Durango, Durango, Mexico., Hernández-Tinoco J; Institute for Scientific Research 'Dr. Roberto Rivera Damm', Juárez University of Durango State, Avenida Universidad S/N, 34000, Durango, Durango, Mexico., Castillo-Orona JM; Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, 34000, Durango, Dgo, Mexico., Salas-Martínez C; Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, 34000, Durango, Dgo, Mexico.; General Hospital, Secretary of Health, Avenida 5 de febrero 220, 34000, Durango, Mexico., Sifuentes-Álvarez A; Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, 34000, Durango, Dgo, Mexico.; General Hospital, Secretary of Health, Avenida 5 de febrero 220, 34000, Durango, Mexico., Sandoval-Carrillo AA; Institute for Scientific Research 'Dr. Roberto Rivera Damm', Juárez University of Durango State, Avenida Universidad S/N, 34000, Durango, Durango, Mexico., Salas-Pacheco JM; Institute for Scientific Research 'Dr. Roberto Rivera Damm', Juárez University of Durango State, Avenida Universidad S/N, 34000, Durango, Durango, Mexico., Liesenfeld O; Institute for Microbiology and Hygiene, Campus Benjamin Franklin, Charité Medical School, Hindenburgdamm 27, D-12203, Berlin, Germany.; Present Address: Medical and Scientific Affairs, Roche Molecular Systems, Pleasanton, CA, 94588, USA., Antuna-Salcido EI; Institute for Scientific Research 'Dr. Roberto Rivera Damm', Juárez University of Durango State, Avenida Universidad S/N, 34000, Durango, Durango, Mexico.
Jazyk:	angličtina
Zdroj:	BMC infectious diseases [BMC Infect Dis] 2017 Mar 06; Vol. 17 (1), pp. 190. Date of Electronic Publication: 2017 Mar 06.
DOI:	10.1186/s12879-017-2292-1
Abstrakt:	Background: Very little is known about the link of T. gondii infection and depression. Through an age-, gender-, and month of pregnancy-matched case-control study, we determined the association of T. gondii infection and depression in pregnant women. Methods: We studied 200 pregnant women with depression and 200 pregnant women without depression attended in a public hospital in Durango City, Mexico. Pregnant women were tested for the presence of anti-Toxoplasma IgG antibodies using an enzyme-linked immunoassay (EIA), and IgG seropositive women were further tested for the presence of IgM using an EIA. IgM positivity by EIA was further analyzed by enzyme-linked fluorescence assay (ELFA). Results: Anti-T. gondii IgG antibodies were found in 9 (4.5%) of the 200 cases and in 12 (6.0%) of the 200 controls (OR = 0.73; 95% CI: 0.30-1.79; P = 0.50). The frequency of high (>150 IU/ml) anti-T. gondii IgG levels was similar in cases and in controls (OR = 1.20; 95% CI: 0.36-4.01; P = 0.75). Two women were positive for IgM by EIA but both were negative by ELFA. Conclusions: We did not find serological evidence of an association between T. gondii infection and depression in pregnant women attended in a public hospital in Durango City, Mexico. Since an association of T. gondii and depression in pregnancy has been reported in the U.S. previously, further research to elucidate the role of T. gondii in prenatal depression should be conducted.
Databáze:	MEDLINE
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