Food for thought: Impact of metabolism on neuronal excitability.

Autor: Katsu-Jiménez Y; Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Scheeles väg 2, 171 77 Stockholm, Sweden., Alves RMP; Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Scheeles väg 2, 171 77 Stockholm, Sweden., Giménez-Cassina A; Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Scheeles väg 2, 171 77 Stockholm, Sweden; Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Department of Molecular Biology, C/ Nicolás Cabrera 1, 28049 Madrid, Spain. Electronic address: agcassina@cbm.csic.es.
Jazyk: angličtina
Zdroj: Experimental cell research [Exp Cell Res] 2017 Nov 01; Vol. 360 (1), pp. 41-46. Date of Electronic Publication: 2017 Mar 03.
DOI: 10.1016/j.yexcr.2017.03.002
Abstrakt: Neuronal excitability is a highly demanding process that requires high amounts of energy and needs to be exquisitely regulated. For this reason, brain cells display active energy metabolism to support their activity. Independently of their roles as energy substrates, compelling evidence shows that the nature of the fuels that neurons use contribute to fine-tune neuronal excitability. Crosstalk of neurons with glial populations also plays a prominent role in shaping metabolic flow in the brain. In this review, we provide an overview on how different carbon substrates and metabolic pathways impact neurotransmission, and the potential implications for neurological disorders in which neuronal excitability is deregulated, such as epilepsy.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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