Significant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population.

Autor: Özdaş T; Yenimahalle Education and Research Hospital, Otolaryngology Clinic, Ankara, Turkey., Özdaş S; Department of Bioengineering, Faculty of Engineering and Natural Sciences, Adana Science and Technology University, Adana, Turkey., Babademez MA; Yenimahalle Education and Research Hospital, Otolaryngology Clinic, Ankara, Turkey., Muz SE; Yenimahalle Education and Research Hospital, Otolaryngology Clinic, Ankara, Turkey., M Atilla H; Yenimahalle Education and Research Hospital, Otolaryngology Clinic, Ankara, Turkey., Baştimur S; Yenimahalle Education and Research Hospital, Otolaryngology Clinic, Ankara, Turkey., Izbirak A; Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey., Kurt K; Yenimahalle Education and Research Hospital, Otolaryngology Clinic, Ankara, Turkey., Öz I; Yenimahalle Education and Research Hospital, Otolaryngology Clinic, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Turkish journal of medical sciences [Turk J Med Sci] 2017 Feb 27; Vol. 47 (1), pp. 201-210. Date of Electronic Publication: 2017 Feb 27.
DOI: 10.3906/sag-1512-93
Abstrakt: Background/aim: Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants or their genetic combinations on AH.
Materials and Methods: We genotyped the SCGB1D4 (IIS) gene in 167 participants (95 children with AH and 72 controls) by performing DNA sequencing in blood samples.
Results: We genotyped three single nucleotide polymorphisms (SNPs). In the analysis, we found that in the presence of those SNPs and the minor alleles of individual SNPs four haplotypes were associated with an increased risk of AH. In addition, those SNPs were significantly associated with asthma, allergy, sleep-disordered breathing, AH grade +4, and a high level of IgE. As indicated on multifactor dimensionality reduction analysis, single-locus (rs35328961), two-locus (rs35328961_rs56196602), and three-locus models (rs200327820_rs35328961_rs56196602) had the highest synergistic interaction effect on AH. The three-factor model was also significantly associated with some genotypes of rs35328961 and allergic-asthmatic AH.
Conclusion: SNPs of SCGB1D4 and their combinations are associated with an increased risk for developing AH. We highlighted the importance of genetic factors on AH and AH-related clinical phenotypes.
Databáze: MEDLINE
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