| Autor: |
Sushkov DG; Institute of Chemical Kinetics and Combustion, Novosibirsk, USSR., Gritsan NP, Weiner LM |
| Jazyk: |
angličtina |
| Zdroj: |
FEBS letters [FEBS Lett] 1987 Dec 10; Vol. 225 (1-2), pp. 139-44. |
| DOI: |
10.1016/0014-5793(87)81146-8 |
| Abstrakt: |
Spin-trapping experiments have shown that 9,10-anthraquinone-2-sulphonate (AQS) can be reduced enzymatically with NADPH-cytochrome P-450 reductase (FP) producing OH radicals. It has been revealed for the first time that the radical anion of AQS cannot decompose H2O2 as indicated by flash-photolysis data. From the experimental results obtained it follows that an enzyme system containing NADPH, AQS and FP produces both accumulation of H2O2 from molecular oxygen and reduction of Fe3+ to Fe2+ which decomposes H2O2 catalytically via a Fenton reaction. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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