Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Autor:	Qi Q; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY qibin.qi@einstein.yu.edu., Stilp AM; Department of Biostatistics, University of Washington, Seattle, WA., Sofer T; Department of Biostatistics, University of Washington, Seattle, WA., Moon JY; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY., Hidalgo B; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL., Szpiro AA; Department of Biostatistics, University of Washington, Seattle, WA., Wang T; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY., Ng MCY; Center for Genomics and Personalized Medicine Research and Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC., Guo X; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, and Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA., Chen YI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, and Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA., Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, and Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA., Aviles-Santa ML; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Papanicolaou G; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Pankow JS; Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN., Schneiderman N; Department of Psychology, University of Miami, Miami, FL., Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, and Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA., Kaplan RC; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY.
Jazyk:	angličtina
Zdroj:	Diabetes [Diabetes] 2017 May; Vol. 66 (5), pp. 1419-1425. Date of Electronic Publication: 2017 Mar 02.
DOI:	10.2337/db16-1150
Abstrakt:	Few genome-wide association studies (GWAS) of type 2 diabetes (T2D) have been conducted in U.S. Hispanics/Latinos of diverse backgrounds who are disproportionately affected by diabetes. We conducted a GWAS in 2,499 T2D case subjects and 5,247 control subjects from six Hispanic/Latino background groups in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Our GWAS identified two known loci ( TCF7L2 and KCNQ1) reaching genome-wide significance levels. Conditional analysis on known index single nucleotide polymorphisms (SNPs) indicated an additional independent signal at KCNQ1 , represented by an African ancestry-specific variant, rs1049549 (odds ratio 1.49 [95% CI 1.27-1.75]). This association was consistent across Hispanic/Latino background groups and replicated in the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium. Among 80 previously known index SNPs at T2D loci, 66 SNPs showed consistency with the reported direction of associations and 14 SNPs significantly generalized to the HCHS/SOL. A genetic risk score based on these 80 index SNPs was significantly associated with T2D (odds ratio 1.07 [1.06-1.09] per risk allele), with a stronger effect observed in nonobese than in obese individuals. Our study identified a novel independent signal suggesting an African ancestry-specific allele at KCNQ1 for T2D. Associations between previously identified loci and T2D were generally shown in a large cohort of U.S. Hispanics/Latinos. (© 2017 by the American Diabetes Association.)
Databáze:	MEDLINE
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