Extended pulsated drug release from PLGA-based minirods.

Autor: Danyuo Y; Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.; Department of Materials Science and Engineering, Kwara State University, Ilorin, Nigeria., E Oberaifo O; Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria., Obayemi JD; Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.; Department of Mechanical and Aerospace Engineering 41 Olden Street, Princeton University, Princeton, NJ, 08544, USA., Dozie-Nwachukwu S; Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.; Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria., J Ani C; Department of Theoretical Physics, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.; Department of Physics, Salem University, Lokoja-Ajaokuta Road, Lokoja, Kogi, Nigeria., Odusanya OS; Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria., Zebaze Kana MG; Department of Materials Science and Engineering, Kwara State University, Ilorin, Nigeria., Malatesta K; Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, 70 Prospect Street, Princeton, NJ, 08544, USA., Soboyejo WO; Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria. soboyejo@princeton.edu.; Department of Mechanical and Aerospace Engineering 41 Olden Street, Princeton University, Princeton, NJ, 08544, USA. soboyejo@princeton.edu.; Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, 70 Prospect Street, Princeton, NJ, 08544, USA. soboyejo@princeton.edu.
Jazyk: angličtina
Zdroj: Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2017 Apr; Vol. 28 (4), pp. 61. Date of Electronic Publication: 2017 Mar 01.
DOI: 10.1007/s10856-017-5866-y
Abstrakt: The kinetics of degradation and sustained cancer drugs (paclitaxel (PT) and prodigiosin (PG)) release are presented for minirods (each with diameter of ~5 and ~6 mm thick). Drug release and degradation mechanisms were studied from solvent-casted cancer drug-based minirods under in vitro conditions in phosphate buffer solution (PBS) at a pH of 7.4. The immersed minirods were mechanically agitated at 60 revolutions per minute (rpm) under incubation at 37 °C throughout the period of the study. The kinetics of drug release was studied using ultraviolet visible spectrometry (UV-Vis). This was used to determine the amount of drug released at 535 nm for poly(lactic-co-glycolic acid) loaded with prodigiosin (PLGA-PG) samples, and at 210 nm, for paclitaxel-loaded samples (PLGA-PT). The degradation characteristics of PLGA-PG and PLGA-PT are elucidated using optical microscope as well as scanning electron microscope (SEM). Statistical analysis of drug release and degradation mechanisms of PLGA-based minirods were performed. The implications of the results are discussed for potential applications in implantable/degradable structures for multi-pulse cancer drug delivery.
Databáze: MEDLINE