Vasoactive intestinal peptide, a promising agent for myopia?

Autor:	Cakmak AI; Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey., Basmak H; Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey., Gursoy H; Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey., Ozkurt M; Department of Physiology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey., Yildirim N; Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey., Erkasap N; Department of Physiology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey., Bilgec MD; Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey., Tuncel N; Department of Physiology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey., Colak E; Department of Biostatistics, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey.
Jazyk:	angličtina
Zdroj:	International journal of ophthalmology [Int J Ophthalmol] 2017 Feb 18; Vol. 10 (2), pp. 211-216. Date of Electronic Publication: 2017 Feb 18 (Print Publication: 2017).
DOI:	10.18240/ijo.2017.02.05
Abstrakt:	Aim: To investigate the role of vasoactive intestinal peptide (VIP) in form-deprivation myopia (FDM). Methods: FDM was created in three groups of eight chicks by placing a translucent diffuser on their right eyes. Intravitreal injections of saline and VIP were applied once a day into the occluded eyes of groups 2 and 3, respectively. Retinoscopy and axial length (AL) measurements were performed on the first and 8 th days of diffuser wear. The retina mRNA levels of the VIP receptors and the ZENK protein in right eyes of the three groups and left eyes of the first group on day 8 were determined using real time polymerase chain reaction (PCR). Results: The median final refraction (D) in right eyes were -13.75 (-16.00, -12.00), -11.50 (-12.50, -7.50), and -1.50 (-4.75, -0.75) in groups 1, 2, and 3, respectively ( P <0.001). The median AL (mm) in right eyes were 10.65 (10.00, 11.10), 9.90 (9.70, 10.00), and 9.20 (9.15, 9.25) in groups 1, 2, and 3, respectively ( P <0.001). The median delta-delta cycle threshold (CT) values for the VIP2 receptors were 1.07 (0.82, 1.43), 1.22 (0.98, 1.65), 0.29 (0.22, 0.45) in right eyes of groups 1, 2, and 3, and 1.18 (0.90, 1.37) in left eyes of group 1, respectively ( P =0.001). The median delta-delta CT values for the ZENK protein were 1.07 (0.63, 5.03), 3.55 (2.20, 5.55), undetectable in right eyes of groups 1, 2, and 3 and 1.89 (0.21, 4.73) in left eyes of group 1, respectively ( P =0.001). Conclusion: VIP has potential inhibitory effects in the development of FDM.
Databáze:	MEDLINE
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