Proliferative and Differentiation Potential of Multipotent Mesenchymal Stem Cells Cultured on Biocompatible Polymer Scaffolds with Various Physicochemical Characteristics.

Autor: Rodina AV; National Research Center Kurchatov Institute, Moscow, Russia. allrodina@yandex.ru., Tenchurin TK; National Research Center Kurchatov Institute, Moscow, Russia., Saprykin VP; A. I. Burnazyan Federal Medical and Biophysical Center, Federal Medical-Biological Agency, Moscow, Russia., Shepelev AD; National Research Center Kurchatov Institute, Moscow, Russia., Mamagulashvili VG; National Research Center Kurchatov Institute, Moscow, Russia., Grigor'ev TE; National Research Center Kurchatov Institute, Moscow, Russia., Moskaleva EY; National Research Center Kurchatov Institute, Moscow, Russia., Chvalun SN; National Research Center Kurchatov Institute, Moscow, Russia., Severin SE; National Research Center Kurchatov Institute, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Feb; Vol. 162 (4), pp. 488-495. Date of Electronic Publication: 2017 Feb 27.
DOI: 10.1007/s10517-017-3646-9
Abstrakt: Biocompatibility of film and fibrous scaffolds from polylactide-based polymers and the relationship between their architecture and the functional characteristics of mesenchymal stem cells were studied. Cell culturing on polylactide-based film and fibrous matrixes did not deteriorate cell morphology and their proliferation and differentiation capacities. The rate of cell proliferation and penetration in microporous 3D matrices with the same porosity parameters and pore size depended on their spatial organization. The above materials can be used as scaffolds for mesenchymal stem cells for creation of tissue engineering implants. The scaffold size and structure should be determined by the defects in the organs in which the regeneration processes have to be stimulated.
Databáze: MEDLINE
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