Statin Use and 25-Hydroxyvitamin D Blood Level Response to Vitamin D Treatment of Older Adults.

Autor: Bischoff-Ferrari HA; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.; Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland., Fischer K; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.; Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland., Orav EJ; Department of Biostatistics, School of Public Health, Harvard University, Boston, Massachusetts., Dawson-Hughes B; U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts., Meyer U; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.; Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland., Chocano-Bedoya PO; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.; Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland., Meyer OW; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.; Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland., Ernst R; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.; Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland., Schietzel S; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.; Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland., Eberli F; Department of Cardiology, Triemli City Hospital, Zurich, Switzerland., Staehelin HB; Department of Geriatrics, University of Basel, Basel, Switzerland., Freystätter G; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.; Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland., Roas S; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland., Theiler R; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.; Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland., Egli A; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.; Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland., Wilson NM; Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.; Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
Jazyk: angličtina
Zdroj: Journal of the American Geriatrics Society [J Am Geriatr Soc] 2017 Jun; Vol. 65 (6), pp. 1267-1273. Date of Electronic Publication: 2017 Feb 27.
DOI: 10.1111/jgs.14784
Abstrakt: Objectives: To determine whether statin use alters response of 25-hydroxyvitamin D (25(OH)D) level to vitamin D treatment.
Design: Pooled analysis.
Setting: Three double-blind randomized controlled trials that tested different doses of vitamin D.
Participants: Participants of three trials (N = 646; mean age 76.3 ± 8.4, 65% female).
Measurements: In all three trials, 25(OH)D status and statin use were assessed repeatedly over time (baseline, 6 and 12 months). Repeated-measures analysis was used to compare 25(OH)D response to vitamin D treatment at baseline and 6 and 12 months of statin users and nonusers, controlling for age, sex, body mass index, Charlson Comorbidity Index, vitamin D dose, trial, and season.
Results: At baseline, 17.5% were statin users, and 65% were vitamin D deficient (25(OH)D < 20 ng/mL). Baseline 25(OH)D levels did not differ significantly between groups at baseline (18.8 for statin users, 17.2 ng/mL for nonusers, P = .07), but according to the longitudinal analyses, the total increase over 12 months in 25(OH)D concentration was significantly lower in statin users (13.1 ng/L) than nonusers (15.9 ng/mL; 21.4% difference; P = .009).
Conclusion: Of persons aged 60 and older at high risk of vitamin D deficiency, statin users had a 21.4% smaller increase in 25(OH)D serum concentrations over time than nonusers, independent of vitamin D dose and other covariates.
(© 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society.)
Databáze: MEDLINE
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