Parkinson's Disease is Accompanied by Intertwined Alterations in Iron Metabolism and Activated Immune-inflammatory and Oxidative Stress Pathways.

Autor:	de Farias CC; Graduation Program in Health Sciences, State University of Londrina (UEL), Parana, Brazil., Maes M; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Bonifacio KL; Graduation Program in Health Sciences, State University of Londrina (UEL), Parana, Brazil., Matsumoto AK; Graduation Program in Health Sciences, State University of Londrina (UEL), Parana, Brazil., Bortolasci CC; Graduation Program in Health Sciences, State University of Londrina (UEL), Parana, Brazil., Nogueira AS; Graduation Program in Health Sciences, State University of Londrina (UEL), Parana, Brazil., Brinholi FF; Graduation Program in Health Sciences, State University of Londrina (UEL), Parana, Brazil., Morimoto HK; Graduation Program in Health Sciences, State University of Londrina (UEL), Parana, Brazil., de Melo LB; Clinical Hospital, UEL, Paraná, Brazil., Moreira EG; Graduation Program in Health Sciences, State University of Londrina (UEL), Parana, Brazil., Barbosa DS; Graduation Program in Health Sciences, State University of Londrina (UEL), Parana, Brazil.
Jazyk:	angličtina
Zdroj:	CNS & neurological disorders drug targets [CNS Neurol Disord Drug Targets] 2017; Vol. 16 (4), pp. 484-491.
DOI:	10.2174/1871527316666170223161004
Abstrakt:	Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by a complex interplay between peripheral and central inflammatory and oxidative stress pathways. Objective: To investigate immune-inflammatory and oxidative stress pathways in relation to iron metabolism in peripheral blood of PD patients and healthy controls. Method: We recruited 56 healthy individuals and 56 PD patients in stages 1-3 of Hoehn and Yahr Scale. Plasma haptoglobin (Hp), homocysteine, interleukin 6, soluble interleukin 6 receptor, iron (Fe), ferritin, total iron binding capacity, transferrin (Tf), soluble transferrin receptor (sTfR), malondialdehyde (MDA) and paraoxonase 1 (PON1) were measured. Results: PD was associated with significant changes in Tf (lowered), sTfR, ferritin, Hp, interleukin 6 and MDA (all increased) levels, while there was a trend towards a negative association with PON1. Logistic regression showed that the most significant biomarkers of PD were MDA, sTfR, Hp and ferritin. Moreover, Fe levels were negatively associated with Hp and positively with PON1, total iron binding capacity and Tf, while ferritin and sTfR were positively associated with MDA levels. Conclusion: Our study indicates a state of systemic inflammation and oxidative stress in PD patients coupled with alterations in Fe metabolism. Chronic inflammation and oxidative pathways in PD may in part determine changes in iron metabolism. New drug treatments for PD should target inflammatory and oxidative stress pathways and iron metabolism as well. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
Databáze:	MEDLINE
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