Molecular prevalence of Merkel cell polyomavirus in nonmelanoma skin cancer in a Brazilian population.

Autor: Bellott TR; Department of Clinical Medicine, Universidade Federal Fluminense, Hospital Universitário Antônio Pedro, Niterói, Rio de Janeiro, Brazil., Baez CF; Department of Preventive Medicine, Universidade Federal do Rio do Janeiro, Brazil., Almeida SG; Department of Preventive Medicine, Universidade Federal do Rio do Janeiro, Brazil., Venceslau MT; Department of Preventive Medicine, Universidade Federal do Rio do Janeiro, Brazil., Zalis MG; Department of Preventive Medicine, Universidade Federal do Rio do Janeiro, Brazil., Guimarães MA; Department of Preventive Medicine, Universidade Federal do Rio do Janeiro, Brazil., Rochael MC; Department of Clinical Medicine, Universidade Federal Fluminense, Hospital Universitário Antônio Pedro, Niterói, Rio de Janeiro, Brazil., Luz FB; Department of Clinical Medicine, Universidade Federal Fluminense, Hospital Universitário Antônio Pedro, Niterói, Rio de Janeiro, Brazil., Varella RB; Department of Microbiology and Parasitology, Universidade Federal Fluminense, Hospital Universitário Antônio Pedro, Niterói, Rio de Janeiro, Brazil., Almeida JR; Department of Clinical Medicine, Universidade Federal Fluminense, Hospital Universitário Antônio Pedro, Niterói, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Clinical and experimental dermatology [Clin Exp Dermatol] 2017 Jun; Vol. 42 (4), pp. 390-394. Date of Electronic Publication: 2017 Feb 27.
DOI: 10.1111/ced.13069
Abstrakt: Background: Merkel cell polyomavirus (MCPyV), a newly described oncogenic virus, has been found in association with tumours other than Merkel cell carcinoma (MCC). As yet, little is known about the involvement or influence of MCPyV on the development of these tumours and its prevalence in various populations.
Aim: To assess the prevalence of MCPyV DNA in cases of nonmelanoma skin cancer (NMSC).
Methods: The prevalence of MCPyV DNA was assessed in 96 cases of NMSC in a Brazilian population comprising 76 subjects, and these results were correlated with epidemiological and demographical data.
Results: MCPyV DNA was detected in 23 of 69 (33.3%) basal cell carcinomas, in 2 of 11 (18%) squamous cell carcinomas, 2 of 4 Bowen disease case, 0 of 1 MCC and 4 of 11 other skin disorders.
Conclusion: Despite the frequent detection of MCPyV DNA in NMSC, its possible role in the development of NMSC still needs further investigation.
(© 2017 British Association of Dermatologists.)
Databáze: MEDLINE
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