MRI Study for the Features of Brain Conduction Pathways in Patients with an Ultra-High Risk of Endogenous Psychoses.

Autor: Tomyshev AS; Mental Health Research Center, Moscow, Russia. alexander.tomyshev@gmail.com., Lebedeva IS; Mental Health Research Center, Moscow, Russia., Akhadov TA; Emergency Children's Surgery and Traumatology Research Institute, Moscow, Russia., Omel'chenko MA; Mental Health Research Center, Moscow, Russia., Ublinskii MV; Emergency Children's Surgery and Traumatology Research Institute, Moscow, Russia.; N. M. Emanuel Institute of Biochemical Physics, Moscow, Russia., Semenova NA; Emergency Children's Surgery and Traumatology Research Institute, Moscow, Russia.; N. M. Emanuel Institute of Biochemical Physics, Moscow, Russia.; N. N. Semenov Institute of Chemical Physics, Moscow, Russia., Kaleda VG; Mental Health Research Center, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Feb; Vol. 162 (4), pp. 425-429. Date of Electronic Publication: 2017 Feb 27.
DOI: 10.1007/s10517-017-3631-3
Abstrakt: Diffusion parameters of brain tracts (n=18) were studied in 27 men with ultra-high risk of endogenous attack-like psychoses and 27 mentally healthy men of the same age group (fractional anisotropy; and average, radial, and axial diffusion). Correlation analysis was performed between these parameters and severity of mental disorders (SOPS scale). The indexes of radial diffusion and axial diffusion were shown to change in the left anterior thalamic radiation and right posterior cingulum bundle, respectively. Our results are consistent with published data that disturbances in the frontal and temporal lobes play an important role in the pathogenesis of schizophrenia. The degree of mental disorders correlated with diffusion parameters in the left and right anterior cingulum bundle.
Databáze: MEDLINE
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