Impairment of Energy-Dependent Processes in the Muscle Tissue as a Pathogenetic Mechanism of Statin-Induced Myopathy.

Autor: Mikashinovich ZI; Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia., Belousova ES; Department of Pharmaceutical Chemistry and Pharmacognosy, Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia. belousovalena@mail.ru., Sarkisyan OG; Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Feb; Vol. 162 (4), pp. 433-435. Date of Electronic Publication: 2017 Feb 27.
DOI: 10.1007/s10517-017-3633-1
Abstrakt: Administration of simvastatin was followed by a decrease in activities of superoxide dismutase and cytochrome oxidase in rat mitochondria, which attested to dysfunction of the respiratory chain. The decrease in total ATPase and Ca 2+ -ATPase activities in muscle tissue homogenates reflected impaired transport of active cations essential for muscle contraction. We conclude that abnormal relationships in the system of energy synthetic and energy-dependent processes in myocytes serve as the molecular basis for the formation of statin-induced degenerative changes.
Databáze: MEDLINE
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