Unsuspected Lung Pathology in Autopsies of Children with Cancer.

Autor:	Furuya ME; Research Unit in Respiratory Diseases, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Rodríguez-Velasco A; Service of Pathology, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Rodríguez-Zepeda MC; Service of Hematology, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., López-Aguilar E; Service Oncology, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Vargas MH; Research Unit in Respiratory Diseases, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Sciandra-Rico M; Service of Pre-School, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Cárdenas-Navarrete R; Service of School Children, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Madrigal-Muñiz O; Neonatal Intensive Care Unit, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Feria-Kaiser C; Neonatal Intensive Care Unit, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Delgado-González EE; Services Infants/Toddlers, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Villasís-Keeverz MÁ; Research Unit in Clinical Epidemiology, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Jazyk:	angličtina
Zdroj:	Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion [Rev Invest Clin] 2017 Jan-Feb; Vol. 69 (1), pp. 28-32.
DOI:	10.24875/ric.17002098
Abstrakt:	Background: Although pulmonary involvement is common in patients with cancer, its frequency and nature is seldom reported in the medical literature. Objective: To determine the frequency and type of lung pathological conditions revealed by autopsy in children with cancer. Methods: All reports from autopsies performed in children with cancer from 1989 to 2012 in a pediatric hospital were reviewed. Results: In the analyzed period, 118 autopsies (10.2% of all autopsies) corresponded to children who died with cancer; 76 had complete information and were included in the analysis. Children were seen in the Hematology (41 cases) or the Oncology (35 cases) services. Their median age at decease was 7 years (range, 15 days to 16.1 years) and 46.1% were females. Main diagnoses were acute lymphoblastic (31 patients) or myeloblastic (10 patients) leukemias and tumors of the central nervous system (12 patients). A pathological respiratory condition was diagnosed antemortem in 31 (40.8%) patients, and at autopsy in 62 (81.6%) cases. Omitted diagnoses occurred in 58 (76.3%) children, being pneumonia (24 cases) and pulmonary hemorrhage (23 cases) the most frequent omissions. Nine patients had clinically unsuspected tumor infiltration or metastases. Conclusions: In these children with cancer, more than 80% of autopsies revealed some lung pathology, mainly of infectious or hemorrhagic nature. Thus, pulmonary involvement should be investigated in all children with cancer in a timely and intentional manner.
Databáze:	MEDLINE
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