Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.

Autor: Dossat AM; Department of Biomedical Sciences, Florida State University, Tallahassee, Florida, USA., Sanchez-Gonzalez MA; Division of Clinical and Translational Research, Larkin Community Hospital, South Miami, Florida, USA., Koutnik AP; Department of Biomedical Sciences, Florida State University, Tallahassee, Florida, USA., Leitner S; Department of Biomedical Sciences, Florida State University, Tallahassee, Florida, USA., Ruiz EL; Department of Biomedical Sciences, Florida State University, Tallahassee, Florida, USA., Griffin B; Department of Biomedical Sciences, Florida State University, Tallahassee, Florida, USA., Rosenberg JT; The National High Magnetic Field Laboratory, Center for Interdisciplinary Magnetic Resonance, Florida State University, Tallahassee, Florida, USA; and., Grant SC; The National High Magnetic Field Laboratory, Center for Interdisciplinary Magnetic Resonance, Florida State University, Tallahassee, Florida, USA; and., Fincham FD; Family Institute, Florida State University, Tallahassee, Florida, USA., Pinto JR; Department of Biomedical Sciences, Florida State University, Tallahassee, Florida, USA; jose.pinto@med.fsu.edu., Kabbaj M; Department of Biomedical Sciences, Florida State University, Tallahassee, Florida, USA; mohamed.kabbaj@med.fsu.edu.
Jazyk: angličtina
Zdroj: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2017 Jun; Vol. 31 (6), pp. 2492-2506. Date of Electronic Publication: 2017 Feb 24.
DOI: 10.1096/fj.201600955RR
Abstrakt: Cardiovascular dysfunction is highly comorbid with mood disorders, such as anxiety and depression. However, the mechanisms linking cardiovascular dysfunction with the core behavioral features of mood disorder remain poorly understood. In this study, we used mice bearing a knock-in sarcomeric mutation, which is exhibited in human hypertrophic cardiomyopathy (HCM), to investigate the influence of HCM over the development of anxiety and depression. We employed behavioral, MRI, and biochemical techniques in young (3-4 mo) and aged adult (7-8 mo) female mice to examine the effects of HCM on the development of anxiety- and depression-like behaviors. We focused on females because in both humans and rodents, they experience a 2-fold increase in mood disorder prevalence vs. males. Our results showed that young and aged HCM mice displayed echocardiographic characteristics of the heart disease condition, yet only aged HCM females displayed anxiety- and depression-like behaviors. Electrocardiographic parameters of sympathetic nervous system activation were increased in aged HCM females vs. controls and correlated with mood disorder-related symptoms. In addition, when compared with controls, aged HCM females exhibited adrenal gland hypertrophy, reduced volume in mood-related brain regions, and reduced hippocampal signaling proteins, such as brain-derived neurotrophic factor and its downstream targets vs. controls. In conclusion, prolonged systemic HCM stress can lead to development of mood disorders, possibly through inducing structural and functional brain changes, and thus, mood disorders in patients with heart disease should not be considered solely a psychologic or situational condition.-Dossat, A. M., Sanchez-Gonzalez, M. A., Koutnik, A. P., Leitner, S., Ruiz, E. L., Griffin, B., Rosenberg, J. T., Grant, S. C., Fincham, F. D., Pinto, J. R. Kabbaj, M. Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.
(© FASEB.)
Databáze: MEDLINE
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