| Autor: |
Leiva-Salinas C; From the Department of Radiology (C.L.S., L.F., P.K.R.), Department of Neurology, Neuro-Oncology Center (D.S.), and Department of Public Health Sciences (J.T.P.), University of Virginia, 1215 Lee St, Charlottesville, VA 22908., Schiff D; From the Department of Radiology (C.L.S., L.F., P.K.R.), Department of Neurology, Neuro-Oncology Center (D.S.), and Department of Public Health Sciences (J.T.P.), University of Virginia, 1215 Lee St, Charlottesville, VA 22908., Flors L; From the Department of Radiology (C.L.S., L.F., P.K.R.), Department of Neurology, Neuro-Oncology Center (D.S.), and Department of Public Health Sciences (J.T.P.), University of Virginia, 1215 Lee St, Charlottesville, VA 22908., Patrie JT; From the Department of Radiology (C.L.S., L.F., P.K.R.), Department of Neurology, Neuro-Oncology Center (D.S.), and Department of Public Health Sciences (J.T.P.), University of Virginia, 1215 Lee St, Charlottesville, VA 22908., Rehm PK; From the Department of Radiology (C.L.S., L.F., P.K.R.), Department of Neurology, Neuro-Oncology Center (D.S.), and Department of Public Health Sciences (J.T.P.), University of Virginia, 1215 Lee St, Charlottesville, VA 22908. |
| Abstrakt: |
Purpose To determine the correlation between metabolic activity at fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and survival in patients with glioblastoma and suspected progression at posttherapy magnetic resonance (MR) imaging. Materials and Methods The authors retrospectively examined the relationship between metabolic activity at FDG PET in the residual lesion identified at brain MR imaging and survival time in 56 patients with glioblastoma who were treated with postoperative concurrent radiation and temozolomide therapy and who underwent FDG PET/computed tomography because of radiologic deterioration at follow-up MR imaging between 2006 and 2015. A normalized metric of metabolic activity in the residual lesion (standardized uptake value ratio [SUV r ]) was calculated as the maximum standardized uptake value (SUV max ) in the tumor relative to that in healthy white matter. The primary end point of the study was survival time from PET. Patients were stratified according to SUV r . Comparisons of risk for death between subgroups were made with the log-hazard ratio of the Cox proportional hazard model. Results There was a significant association between overall survival and SUV r in the residual lesion (P = .006), and a survival benefit was observed in patients with SUV r of less than 1.7, who had a median survival time of 23.1 months (95% confidence interval [CI]: 12.7, 38.9), which was significantly longer than that in patients with an SUV r of 2.0 to less than 2.5 and those with an SUV r of at least 2.5, who had a median survival time of 10.1 (95% CI: 2.4, 15.9; P = .008) and 7.5 (95% CI: 3.9, 9.7; P < .001) months, respectively. Conclusion Patients with glioblastoma whose posttherapy MR images showed a residual lesion with high relative metabolic activity at FDG PET had a shorter survival time than did those with low activity at FDG PET. © RSNA, 2016. |
