| Autor: |
Ripamonti S; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.; Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy., Ambrozkiewicz MC; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.; Cortical Development, Institute of Cell Biology and Neurobiology, Charité-Universitätsmedizin, Berlin, Germany., Guzzi F; Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.; NeuroMi - Milan Center for Neuroscience, Monza, Italy., Gravati M; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy., Biella G; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy., Bormuth I; Cortical Development, Institute of Cell Biology and Neurobiology, Charité-Universitätsmedizin, Berlin, Germany., Hammer M; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany., Tuffy LP; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany., Sigler A; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany., Kawabe H; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany., Nishimori K; Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan., Toselli M; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy., Brose N; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany., Parenti M; Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.; NeuroMi - Milan Center for Neuroscience, Monza, Italy., Rhee J; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany. |
| Abstrakt: |
Beyond its role in parturition and lactation, oxytocin influences higher brain processes that control social behavior of mammals, and perturbed oxytocin signaling has been linked to the pathogenesis of several psychiatric disorders. However, it is still largely unknown how oxytocin exactly regulates neuronal function. We show that early, transient oxytocin exposure in vitro inhibits the development of hippocampal glutamatergic neurons, leading to reduced dendrite complexity, synapse density, and excitatory transmission, while sparing GABAergic neurons. Conversely, genetic elimination of oxytocin receptors increases the expression of protein components of excitatory synapses and excitatory synaptic transmission in vitro . In vivo , oxytocin-receptor-deficient hippocampal pyramidal neurons develop more complex dendrites, which leads to increased spine number and reduced γ-oscillations. These results indicate that oxytocin controls the development of hippocampal excitatory neurons and contributes to the maintenance of a physiological excitation/inhibition balance, whose disruption can cause neurobehavioral disturbances. |
