A clinically relevant in vivo model for the assessment of scaffold efficacy in abdominal wall reconstruction.

Autor: Chan JC; Department of Plastic, Reconstructive and Hand Surgery, University Hospital Galway, Galway, Ireland; CÚRAM-Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland., Burugapalli K; Biomedical Engineering Theme, Institute of Environment, Health and Societies, Brunel University London, Uxbridge, UK., Huang YS; CÚRAM-Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland., Kelly JL; Department of Plastic, Reconstructive and Hand Surgery, University Hospital Galway, Galway, Ireland; CÚRAM-Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland., Pandit A; CÚRAM-Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
Jazyk: angličtina
Zdroj: Journal of tissue engineering [J Tissue Eng] 2016 Dec 30; Vol. 8, pp. 2041731416686532. Date of Electronic Publication: 2016 Dec 30 (Print Publication: 2017).
DOI: 10.1177/2041731416686532
Abstrakt: An animal model that allows for assessment of the degree of stretching or contraction of the implant area and the in vivo degradation properties of biological meshes is required to evaluate their performance in vivo. Adult New Zealand rabbits underwent full thickness subtotal unilateral rectus abdominis muscle excision and were reconstructed with the non-biodegradable Peri-Guard ® , Prolene ® or biodegradable Surgisis ® meshes. Following 8 weeks of recovery, the anterior abdominal wall tissue samples were collected for measurement of the implant dimensions. The Peri-Guard and Prolene meshes showed a slight and obvious shrinkage, respectively, whereas the Surgisis mesh showed stretching, resulting in hernia formation. Surgisis meshes showed in vivo biodegradation and increased collagen formation. This surgical rabbit model for abdominal wall defects is advantageous for evaluating the in vivo behaviour of surgical meshes. Implant area stretching and shrinkage were detected corresponding to mesh properties, and histological analysis and stereological methods supported these findings.
Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.
Databáze: MEDLINE
Externí odkaz: