| Autor: |
Hornung CH; CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia., Álvarez-Diéguez MÁ; CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia., Kohl TM; CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia., Tsanaktsidis J; CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia. |
| Abstrakt: |
This work describes the Diels-Alder reaction of the naturally occurring substituted butadiene, myrcene, with a range of different naturally occurring and synthetic dienophiles. The synthesis of the Diels-Alder adduct from myrcene and acrylic acid, containing surfactant properties, was scaled-up in a plate-type continuous-flow reactor with a volume of 105 mL to a throughput of 2.79 kg of the final product per day. This continuous-flow approach provides a facile alternative scale-up route to conventional batch processing, and it helps to intensify the synthesis protocol by applying higher reaction temperatures and shorter reaction times. |
