| Autor: |
Caggiari G; Orthopaedic Department, University of Sassari, Sassari, Italy., Leali PT; Orthopaedic Department, University of Sassari, Sassari, Italy., Mosele GR; Orthopaedic Department, University of Sassari, Sassari, Italy., Puddu L; Orthopaedic Department, University of Sassari, Sassari, Italy., Badessi F; Department of Clinical Endocrinology, University of Sassari, Sassari, Italy., Doria C; Orthopaedic Department, University of Sassari, Sassari, Italy. |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases [Clin Cases Miner Bone Metab] 2016 Sep-Dec; Vol. 13 (3), pp. 200-203. Date of Electronic Publication: 2017 Feb 10. |
| DOI: |
10.11138/ccmbm/2016.13.3.200 |
| Abstrakt: |
In this work we study the safety and effectiveness of teriparatide and alendronate in patients with postmenopausal osteoporosis at high risk of fracture; it was a double-blinded and it was done by examining the comparisons between teriparatide 20 μg/day and alendronate 10 mg/day. Safety and effectiveness analyses were based on data from 355 woman with a mean age of 68 years. Two groups (A and B) with T-score ≤-2.5 at bone mineral density were analyzed and 3 or more vertebral fractures on radiograph. Group A: was treated with teriparatide 20 μg/day and composed from 182 women, in post-menopausal age, without a history of cancer. Group B: was treated with alendronate 10 mg/day composed from 173 women, postmenopausal age, with previous history of cancer (non-active during the study). Clinical evaluations were on bone turnover markers (alkaline phosphatase, procollagene type 1 N -terminal propeptide, and N -telopeptide cross-links), dual-energy X-ray absorptiometry and health-related quality of life (HrQoL). Safety was assessed by reporting of adverse drug reactions (ADRs). The results of this study imply that teriparatide comparated with alendronate has a favorable safety profile and is effective in the treatment of patients with osteoporosis at high risk of fracture. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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