T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow.

Autor:	Glatman Zaretsky A; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Konradt C; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Dépis F; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA., Wing JB; Laboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan., Goenka R; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Atria DG; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Silver JS; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Cho S; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Wolf AI; The Wistar Institute, Philadelphia, PA 19104, USA., Quinn WJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Engiles JB; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Brown DC; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Beiting D; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Erikson J; The Wistar Institute, Philadelphia, PA 19104, USA., Allman D; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Cancro MP; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sakaguchi S; Laboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan., Lu LF; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Benoist CO; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA., Hunter CA; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: chunter@vet.upenn.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2017 Feb 21; Vol. 18 (8), pp. 1906-1916.
DOI:	10.1016/j.celrep.2017.01.067
Abstrakt:	Long-lived plasma cells (PCs) in the bone marrow (BM) are a critical source of antibodies after infection or vaccination, but questions remain about the factors that control PCs. We found that systemic infection alters the BM, greatly reducing PCs and regulatory T (Treg) cells, a population that contributes to immune privilege in the BM. The use of intravital imaging revealed that BM Treg cells display a distinct behavior characterized by sustained co-localization with PCs and CD11c-YFP + cells. Gene expression profiling indicated that BM Treg cells express high levels of Treg effector molecules, and CTLA-4 deletion in these cells resulted in elevated PCs. Furthermore, preservation of Treg cells during systemic infection prevents PC loss, while Treg cell depletion in uninfected mice reduced PC populations. These studies suggest a role for Treg cells in PC biology and provide a potential target for the modulation of PCs during vaccine-induced humoral responses or autoimmunity. (Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu