Zebrafish models in neuropsychopharmacology and CNS drug discovery.

Autor: Khan KM; Department of Psychology, University of Southern Mississippi, Hattiesburg, MS, USA., Collier AD; Department of Psychology, University of Southern Mississippi, Hattiesburg, MS, USA.; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA., Meshalkina DA; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia., Kysil EV; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia., Khatsko SL; Ural Federal University, Ekaterinburg, Russia., Kolesnikova T; Ural Federal University, Ekaterinburg, Russia., Morzherin YY; Ural Federal University, Ekaterinburg, Russia., Warnick JE; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.; Department of Behavioral Sciences, Arkansas Tech University, Russellville, AR, USA., Kalueff AV; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.; Ural Federal University, Ekaterinburg, Russia.; Research Institute of Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China., Echevarria DJ; Department of Psychology, University of Southern Mississippi, Hattiesburg, MS, USA.; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
Jazyk: angličtina
Zdroj: British journal of pharmacology [Br J Pharmacol] 2017 Jul; Vol. 174 (13), pp. 1925-1944. Date of Electronic Publication: 2017 Apr 05.
DOI: 10.1111/bph.13754
Abstrakt: Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets.
(© 2017 The British Pharmacological Society.)
Databáze: MEDLINE
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