Profile of infections in renal transplant recipients from India.

Autor: Kumar A; Department of Nephrology, Command Hospital, Lucknow, Uttar Pradesh, India., Agarwal C; Department of Nephrology, Command Hospital, Lucknow, Uttar Pradesh, India., Hooda AK; Department of Nephrology, Command Hospital, Lucknow, Uttar Pradesh, India., Ojha A; Department of Medicine, AFMC, Pune, Maharashtra, India., Dhillon M; Department of Medicine, Military Hospital, Ambala, India., Hari Kumar KV; Department of Endocrinology, Army Hospital (R and R), Delhi, India.
Jazyk: angličtina
Zdroj: Journal of family medicine and primary care [J Family Med Prim Care] 2016 Jul-Sep; Vol. 5 (3), pp. 611-614.
DOI: 10.4103/2249-4863.197320
Abstrakt: Background: Infectious disorders are a major cause of concern in renal transplant recipients (RTRs) leading to considerable morbidity and mortality. We studied the profile and outcomes of infectious disorders in a cohort of RTR.
Materials and Methods: In this prospective, observational study, we evaluated all RTR who presented with the features of infection. We also included asymptomatic patients with microbiological evidence of infection. We excluded patients with acute rejection, drug toxicity, and malignancy. Descriptive statistics were used to analyze the results.
Results: The study population ( n = 45, 35 male and 10 female) had a mean age of 35.5 ± 10.4 years and follow-up after transplant was 2.1 ± 1.7 years. Urinary tract infection (UTI, n = 15) is the most common infection followed by tuberculosis (TB, n = 8), cytomegalovirus ( n = 6), candidiasis ( n = 7), and hepatitis ( n = 11). Miscellaneous infections such as cryptosporidiosis and pneumocystis were seen in 10 patients. Simultaneous infections with two organisms were seen in 7 patients. Four patients succumbed to multiorgan dysfunction following sepsis, another 4 patients developed chronic graft dysfunction, while the remaining 35 RTR had a good graft function.
Conclusion: Infectious complications are very common in the posttransplant period including UTI and TB. Further large scale studies are required to identify the potential risk factors leading to infections in RTR.
Competing Interests: There are no conflicts of interest.
Databáze: MEDLINE
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