Anxiolytic- and antidepressant-like effects of an aqueous extract of Tanacetum parthenium L. Schultz-Bip (Asteraceae) in mice.

Autor: Cárdenas J; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Coyoacán, 04510 Ciudad de México (CDMX), México., Reyes-Pérez V; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Coyoacán, 04510 Ciudad de México (CDMX), México; Facultad de Química, Universidad Autónoma del Estado de México (UAEM), Toluca, Estado de México, México; Laboratorio de Fitofarmacología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (INPRFM), Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Del. Tlalpan, 14370 CDMX, México., Hernández-Navarro MD; Facultad de Química, Universidad Autónoma del Estado de México (UAEM), Toluca, Estado de México, México., Dorantes-Barrón AM; Laboratorio de Fitofarmacología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (INPRFM), Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Del. Tlalpan, 14370 CDMX, México., Almazán S; Departamento de Bioelectrónica, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (INPRFM), Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Del. Tlalpan, 14370 CDMX, México., Estrada-Reyes R; Laboratorio de Fitofarmacología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (INPRFM), Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Del. Tlalpan, 14370 CDMX, México. Electronic address: estrarosa@hotmail.com.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2017 Mar 22; Vol. 200, pp. 22-30. Date of Electronic Publication: 2017 Feb 16.
DOI: 10.1016/j.jep.2017.02.023
Abstrakt: Aim: Tanacetum parthenium L. Schultz-Bip (Asteraceae) is widely used worldwide in traditional medicine for the treatment of convulsions and culture-bound syndromes such as susto (fear). The aim of this work was to evaluate the anxiolytic- and antidepressant-like effects of an aqueous extract of T. parthenium in behavioral paradigms in mice. The effects of T. parthenium were compared with those produced by anxiolytic and antidepressant drugs. We carried out the chemical characterization of the main constituents of T. parthenium. The involvement with the GABAergic and serotoninergic neurotransmitter systems were explored be means of synergic and antagonist experiments.
Materials and Methods: The anxiolytic-like effect was evaluated using the Burying Behavior Test (BBT) and the Elevated Plus-Maze Test (PMT). The antidepressant-like effect was evaluated in the Forced Swimming Test (FST), and ambulatory activity was assessed in the Open Field Test (OFT). Employing the behavioral tests, synergism and antagonism experiments with Alprazolam, Muscimol, and Picrotoxin were carried out in the PMT. In a series of independent experiments, concomitant administration of T. parthenium and Alprazolam, Fluoxetine, or p-chlorophenylalanine were conducted in the FST. For chemical characterization, High-Performance Liquid Chromatography-Electro Spray Ionization-Mass Spectrometry (HPLC-ESI-MS) analysis was performed.
Results: T. parthenium exerts clear anxiolytic- and antidepressant-like effects in mice, without affecting the ambulatory activity of the experimental subjects.
Conclusions: Anxiolytic- and antidepressant-like T. parthenium effects result, at least part from the involvement of the GABAergic system. Our results support the use of Tanacetum parthenium in traditional medicine and suggest its therapeutic potential in the comorbid anxiety and depression.
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Databáze: MEDLINE