Hepatitis E Virus Infects Neurons and Brains.

Autor:	Zhou X; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Huang F; Medical Faculty, Kunming University of Science and Technology, China., Xu L; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Lin Z; Departments of Neuroscience, and., de Vrij FMS; Psychiatry, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Ayo-Martin AC; Psychiatry, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., van der Kroeg M; Psychiatry, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Zhao M; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Yin Y; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Wang W; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Cao W; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Wang Y; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Kushner SA; Psychiatry, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Marie Peron J; Service d'Hépato-Gastro-Entérologie, Hopital Purpan, and.; Université Paul Sabatier, Toulouse, France., Alric L; Université Paul Sabatier, Toulouse, France.; MR 152 IRD-Toulouse 3 University, France Internal Medicine, Digestive Department, Purpan, France., de Man RA; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Jacobs BC; Departments of Neurology, and.; Immunology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., van Eijk JJ; Department of Neurology, Jeroen Bosch Ziekenhuis, 's-Hertogenbosch., Aronica EMA; Department of (Neuro)Pathology, Academisch Medisch Centrum, Amsterdam-Zuidoost, and., Sprengers D; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Metselaar HJ; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., de Zeeuw CI; Departments of Neuroscience, and.; Netherlands Institute for Neuroscience, Royal Dutch Academy for Arts and Science, Amsterdam., Dalton HR; Royal Cornwall Hospital, and.; European Centre for Environment & Human Health, University of Exeter, Truro, United Kingdom., Kamar N; MR 152 IRD-Toulouse 3 University, France Internal Medicine, Digestive Department, Purpan, France.; Department of Nephrology and Organ Transplantation, CHU Rangueil, and.; INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France., Peppelenbosch MP; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Pan Q; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2017 Apr 15; Vol. 215 (8), pp. 1197-1206.
DOI:	10.1093/infdis/jix079
Abstrakt:	Hepatitis E virus (HEV), as a hepatotropic virus, is supposed to exclusively infect the liver and only cause hepatitis. However, a broad range of extrahepatic manifestations (in particular, idiopathic neurological disorders) have been recently reported in association with its infection. In this study, we have demonstrated that various human neural cell lines (embryonic stem cell-derived neural lineage cells) induced pluripotent stem cell-derived human neurons and primary mouse neurons are highly susceptible to HEV infection. Treatment with interferon-α or ribavirin, the off-label antiviral drugs for chronic hepatitis E, exerted potent antiviral activities against HEV infection in neural cells. More importantly, in mice and monkey peripherally inoculated with HEV particles, viral RNA and protein were detected in brain tissues. Finally, patients with HEV-associated neurological disorders shed the virus into cerebrospinal fluid, indicating a direct infection of their nervous system. Thus, HEV is neurotropic in vitro, and in mice, monkeys, and possibly humans. These results challenge the dogma of HEV as a pure hepatotropic virus and suggest that HEV infection should be considered in the differential diagnosis of idiopathic neurological disorders. (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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