High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil.

Autor:	Ribeiro MG; Universidade Federal de Sergipe, Laboratório de Entomologia e Parasitologia Tropical, Departamento de Morfologia, São Cristóvão, SE, Brasil., Marcolino LD; Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Departamento de Patologia, Botucatu, SP, Brasil., Ramos BR; Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Departamento de Patologia, Botucatu, SP, Brasil., Miranda EA; Universidade Federal de Sergipe, Departamento de Odontologia, Aracaju, SE, Brasil., Trento CL; Universidade Federal de Sergipe, Departamento de Odontologia, Aracaju, SE, Brasil., Jain S; Universidade Federal de Sergipe, Laboratório de Entomologia e Parasitologia Tropical, Departamento de Morfologia, São Cristóvão, SE, Brasil., Gurgel RQ; Universidade Federal de Sergipe, Departamento de Medicina, Aracaju, SE, Brasil., Silva MG; Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Departamento de Patologia, Botucatu, SP, Brasil., Dolabella SS; Universidade Federal de Sergipe, Laboratório de Entomologia e Parasitologia Tropical, Departamento de Morfologia, São Cristóvão, SE, Brasil.
Jazyk:	angličtina
Zdroj:	Journal of applied oral science : revista FOB [J Appl Oral Sci] 2017 Jan-Feb; Vol. 25 (1), pp. 69-74.
DOI:	10.1590/1678-77572016-0313
Abstrakt:	Objective: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil. Material and Methods: We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers. Genotyping was performed by multiplex PCR. Results: Benign, premalignant and malignant lesions were diagnosed by histopathology. HPV was detected in 17 samples. Of these, HPV-6 was detected in 10 samples, HPV-18 in four and HPV-16 in one sample. When samples were categorized by lesion types, HPV was detected in two papilloma cases (2/3), five carcinomas (5/6), one hyperplasia (1/1) and nine dysplasia cases (9/11). Conclusion: Unlike other studies in the literature, we reported high occurrence of HPV in oral lesions. Further studies are required to enhance the comprehension of natural history of oral lesions.
Databáze:	MEDLINE
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