Assessment of hypoxic stress in 44 women with breast cancer in the West Algeria.

Autor:	Medjdoub A; Biology Laboratory of Development and Differentiation, Faculty of Science of Nature and Life, University of Oran 1 Ahmed Ben Bella, Algeria.; Faculty of Nature and Life, University of Science and Technology, Mohamed Boudiaf Oran, Algeria., Tahari Z; Biology Laboratory of Development and Differentiation, Faculty of Science of Nature and Life, University of Oran 1 Ahmed Ben Bella, Algeria.; Faculty of Nature and Life, University of Science and Technology, Mohamed Boudiaf Oran, Algeria., Belhabri L; Pasteur Institut of Oran, Street Gambetta Sylvain Parent Cave Gay, Oran, Algeria., Sahraoui T; Biology Laboratory of Development and Differentiation, Faculty of Science of Nature and Life, University of Oran 1 Ahmed Ben Bella, Algeria., El Kebir FZ; Biology Laboratory of Development and Differentiation, Faculty of Science of Nature and Life, University of Oran 1 Ahmed Ben Bella, Algeria.
Jazyk:	angličtina
Zdroj:	The Gulf journal of oncology [Gulf J Oncolog] 2016 Sep; Vol. 1 (22), pp. 47-50.
Abstrakt:	Aim: The objective of this study was to evaluate the expression of hypoxia-inducible transcription factor 1α (HIF1α) protein profile among women with breast cancer in a population of western Algerian and to correlate the intensity of this expression with prognosis histological grade Scarff Bloom and Richardson (SBR) of the disease and the age of the patients. Methods: We used a kit provided by Life Science Inc (UScnk) for a sandwich enzyme immunoassay for the quantitative measurement of in vitro HIF1α in plasma in 44 patients and 44 controls in a population of western Algerian. Then we looked for the correlation between the intensity of the expression of HIF1α and prognosis histological grade SBR and the age of the patients studied. Results: The results indicate high levels of HIF1α at SBRIII grade with an average value of 12.26 ± 0.5 ng/ml. The average age of patients is around 50 ± 1year. In healthy subjects the mean concentration of 1.88 ± 0.1 ng/ml represents HIF1α with a mean age of 49 ± 1year. Conclusion: Clinical monitoring of patients treated for breast cancer by assaying the HIF1α marker seems to be very important in the prognosis.
Databáze:	MEDLINE
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