Genomic sequencing of a strain of Acinetobacter baumannii and potential mechanisms to antibiotics resistance.

Autor: Zhao L; Department of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, China; Department of Molecular Biology, Institute of Bacterium Resistance, Anhui Medical University, China; Department of Molecular Biology, Anhui Center for Surveillance of Bacterial Resistance, Hefei, China., Li H; Department of Clinical Medicine, Xiangya Hospital Central South University, Changsha, China., Zhu Z; Department of Surgery, University of Missouri School of Medicine, Columbia, MO, USA., Wakefield MR; Department of Surgery, University of Missouri School of Medicine, Columbia, MO, USA., Fang Y; Department of Surgery, University of Missouri School of Medicine, Columbia, MO, USA; Department of Microbiology, Immunology & Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, USA. Electronic address: yujiang.fang@dmu.edu., Ye Y; Department of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, China; Department of Molecular Biology, Institute of Bacterium Resistance, Anhui Medical University, China; Department of Molecular Biology, Anhui Center for Surveillance of Bacterial Resistance, Hefei, China. Electronic address: yeying2@139.com.
Jazyk: angličtina
Zdroj: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2017 Jun; Vol. 50, pp. 20-24. Date of Electronic Publication: 2017 Feb 09.
DOI: 10.1016/j.meegid.2017.02.001
Abstrakt: Acinetobacter baumannii has been becoming a great challenge to clinicians due to their resistance to almost all available antibiotics. In this study, we sequenced the genome from a multiple antibiotics resistant Acinetobacter baumannii stain which was named A. baumannii-1isolated from China by SMRT sequencing technology to explore its potential mechanisms to antibiotic resistance. We found that several mechanisms might contribute to the antibiotic resistance of Acinetobacter baumannii. Specifically, we found that SNP in genes associated with nucleotide excision repair and ABC transporter might contribute to its resistance to multiple antibiotics; we also found that specific genes associated with bacterial DNA integration and recombination, DNA-mediated transposition and response to antibiotics might contribute to its resistance to multiple antibiotics; Furthermore, specific genes associated with penicillin and cephalosporin biosynthetic pathway and specific genes associated with CHDL and MBL β-lactamase genes might contribute to its resistance to multiple antibiotics. Thus, the detailed mechanisms by which Acinetobacter baumannii show extensive resistance to multiple antibiotics are very complicated. Such a study might be helpful to develop new strategies to control Acinetobacter baumannii infection.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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