Oral application of carbon nanofibers in rats increases blood concentration of IL6 and IL10 and decreases locomotor activity.

Autor: Sayapina NV; Far Eastern Federal University, Vladivostok, Russian Federation; Amur State Medical Academy, Blagoveshchensk, Russian Federation., Batalova TA; Amur State Medical Academy, Blagoveshchensk, Russian Federation., Sergievich AA; Far Eastern Federal University, Vladivostok, Russian Federation., Shtarberg MA; Amur State Medical Academy, Blagoveshchensk, Russian Federation., Borodin EA; Amur State Medical Academy, Blagoveshchensk, Russian Federation., Khoroshikh PP; Technical Institute (branch) of North Eastern Federal University, Nerungri, Russian Federation., Chaika VV; Far Eastern Federal University, Vladivostok, Russian Federation., Kodintsev VV; Far Eastern Federal University, Vladivostok, Russian Federation., Vedyagin AA; Boreskov Institute of Catalysis, Novosibirsk, Russian Federation., Mishakov IV; Boreskov Institute of Catalysis, Novosibirsk, Russian Federation., Vakis A; Department of Neurosurgery, University of Crete, Medical School, Heraklion University Hospital, Voutes, 71 021 Heraklion, Crete, Greece., Henrich-Noack P; Institute of Medical Psychology, Otto-von-Guericke University, Magdeburg, Germany., Tsatsakis AM; Department of Forensic Sciences and Toxicology, Medical School, University of Crete, Heraklion, Greece. Electronic address: tsatsaka@uoc.gr., Engin AB; Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey., Golokhvast K; Far Eastern Federal University, Vladivostok, Russian Federation. Electronic address: droopy@mail.ru.
Jazyk: angličtina
Zdroj: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2017 Mar; Vol. 50, pp. 183-191. Date of Electronic Publication: 2017 Jan 24.
DOI: 10.1016/j.etap.2017.01.015
Abstrakt: Carbon nanofibers (CNF) are versatile nanomaterials that are widely used in various fields of science and technology. As a consequence, animals as well as humans may be exposed to such compounds via different routes. We hypothesized that oral intake of CNF will lead to an inflammatory reaction and consequently induce behavioral impairments. To address this issue, rats were fed with 500mg/kgCNF for 14days and their locomotor activity, emotional status and cognition were quantified by testing the animals in an open field set-up, elevated plus maze and in the universal problem solving box which provides information about motivation and cognition. The behavioral tests were performed 3 times within 10days. At the end of the experiment, blood samples were collected and the plasma concentrations of IL-6, IL-8, IL-1β, IL-10 and IL-18 were measured. Our results demonstrated an inflammatory reaction determined by a significantly elevated IL-6 concentration. This, however, was counteracted by an even more pronounced increase in IL-10. The behavioral effects were restricted mainly to a decrease in locomotor activity which was significant in the open field test, as well as the elevated plus maze. Other parameters indicative of cognitive performance were not influenced and also the emotional status was largely unaffected. In conclusion, our results revealed that oral intake of 500mg/kgCNF induced some adverse effects, which, however, can be still partially compensated by the organism.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: