Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation.

Autor:	Fielding CA; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Weekes MP; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Department of Cell Biology, Harvard Medical School, Boston, United States., Nobre LV; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Ruckova E; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Wilkie GS; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, United States., Chang C; Immunology Division, Department of Pathology, University of Cambridge, Cambridge, United Kingdom., Suárez NM; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom., Davies JA; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Antrobus R; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Stanton RJ; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Aicheler RJ; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Nichols H; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Vojtesek B; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Trowsdale J; Immunology Division, Department of Pathology, University of Cambridge, Cambridge, United Kingdom., Davison AJ; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, United States., Tomasec P; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Lehner PJ; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Wilkinson GW; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2017 Feb 10; Vol. 6. Date of Electronic Publication: 2017 Feb 10.
DOI:	10.7554/eLife.22206
Abstrakt:	The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel natural killer (NK) cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1300 cell surface and ~7200 whole cell proteins, we demonstrate that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors. US18 and US20 work in concert to suppress cell surface expression of the critical NKp30 ligand B7-H6 thus inhibiting NK cell activation. The US12 family is therefore identified as a major new hub of immune regulation.
Databáze:	MEDLINE
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