Effect of Androgen on Normal Biodistribution of [ 18 F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in Athymic Non-tumor-bearing Male Mice.

Autor: Jadvar H; Department of Radiology, USC Molecular Imaging Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, U.S.A. jadvar@med.usc.edu., Park R; Department of Radiology, USC Molecular Imaging Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, U.S.A., Yap LP; Department of Radiology, USC Molecular Imaging Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, U.S.A., Chen K; Department of Radiology, USC Molecular Imaging Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, U.S.A., Hughes L; Department of Radiology, USC Molecular Imaging Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, U.S.A., Conti P; Department of Radiology, USC Molecular Imaging Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, U.S.A.
Jazyk: angličtina
Zdroj: Anticancer research [Anticancer Res] 2017 Feb; Vol. 37 (2), pp. 475-479.
DOI: 10.21873/anticanres.11339
Abstrakt: Aim: We assessed the association between the presence and absence of androgen on the normal biodistribution of the positron emission tomography (PET) cellular proliferation imaging biomarker, [ 18 F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil ( 18 F-FMAU), in mice.
Materials and Methods: Non-castrated (n=4) and castrated (n=4) athymic non-tumor-bearing male mice served as models for presence and absence, respectively, of androgen. MicroPET-CT scans were performed 1 h following tail vein administration of 200 uCi of 18 F-FMAU. Imaging was performed at baseline and then at 7-day intervals longitudinally for 35 days only in castrated mice following subcutaneous introduction of a 12.5 mg, 21-day release, dihydrotestosterone pellet. Mean standardized uptake values (SUV mean ) were obtained for liver, heart, and muscle. Several two-group comparisons of average of SUV mean were performed.
Results: Pre-pellet baseline average SUV mean (±s.d.) values in castrated mice were significantly lower than baseline non-castrated values, increased on day 15 and reached peak values on day 28, at which time they were significantly higher than corresponding baseline levels in both non-castrated and pre-pellet castrated mice. The peak values decreased significantly following dihydrotestosterone withdrawal.
Conclusion: There is a significant modulatory effect of androgen on normal 18 F-FMAU uptake levels in mice liver, heart and muscle tissues.
(Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze: MEDLINE
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