Transient elastography evaluation of hepatic and spleen stiffness in patients with hepatosplenic schistosomiasis.

Autor:	Veiga ZST; aDepartment of Gastroenterology and Hepatology, Bonsucesso Federal Hospital bDepartment of Internal Medicine, School of Medicine cInfectious and Parasitic Disease Service, Clementino Fraga Filho University Hospital dDepartment of Immunology, Paulo de Góes Microbiology Institute eDepartment of Radiology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro fDepartment of Gastroenterology, University of the State of Rio de Janeiro gD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil., Villela-Nogueira CA, Fernandes FF, Cavalcanti MG, Figueiredo FA, Pereira JL, Pereira GH, Moraes Coelho HS, Peralta JM, Marques CE, Perez RM, Fogaça HS
Jazyk:	angličtina
Zdroj:	European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2017 Jun; Vol. 29 (6), pp. 730-735.
DOI:	10.1097/MEG.0000000000000853
Abstrakt:	Background: Hepatosplenic schistosomiasis (HES) has not been evaluated by transient elastography so far and its correlation with ultrasound variables remains to be defined. Aims: The aim of this study was to describe the parameters of liver and spleen stiffness in HES assessed by transient elastography in comparison with cirrhotics and controls evaluating its correlation with ultrasonographic data. Patients and Methods: HES, hepatitis C virus-cirrhotic, and control patients were included in this sectional study. Liver and spleen stiffness were compared among the three groups. The ultrasonographic parameters were compared with transient elastography in HES patients. Results: Thirty HES, 30 hepatitis C virus-cirrhotic patients, and 17 controls were included. Those with HES presented liver stiffness that was significantly higher than the controls and lower than the cirrhotics: 9.7 (3.6-75.0) versus 3.7 (2.8-5.4) versus 27.0 (14.7-61.5) kPa (P<0.001). Spleen stiffness values were comparable between hepatosplenic and cirrhotics: 66.4 (25.7-75.0) versus 69.1 (18.0-75.0) kPa (P=0.78) and were significantly higher than the controls 16.5 kPa (6.3-34.3) (P<0.001). In patients with HES, high spleen stiffness was associated with right liver lobe diameter (P=0.015), splenic artery resistance index (P=0.002), portal vein diameter (P=0.021), portal vein area (P=0.008), portal vein congestion index (P=0.035), splenic vein diameter (P=0.013), and spleen diameter (P=0.021). Conclusion: Liver stiffness may be a useful tool to differentiate portal hypertension related to cirrhosis from that of HES. High spleen stiffness is a potential surrogate marker of portal hypertension in this population.
Databáze:	MEDLINE
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