Impact of hot and cold exposure on human skeletal muscle gene expression.

Autor: Zak RB; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA.; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA., Shute RJ; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA.; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA., Heesch MW; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA.; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA., La Salle DT; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA.; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA., Bubak MP; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA.; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA., Dinan NE; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA.; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA., Laursen TL; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA.; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA., Slivka DR; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA.; Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, University of Nebraska-Omaha, Omaha, NE 68182, USA.
Jazyk: angličtina
Zdroj: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2017 Mar; Vol. 42 (3), pp. 319-325. Date of Electronic Publication: 2016 Dec 01.
DOI: 10.1139/apnm-2016-0415
Abstrakt: Many human diseases lead to a loss of skeletal muscle metabolic function and mass. Local and environmental temperature can modulate the exercise-stimulated response of several genes involved in mitochondrial biogenesis and skeletal muscle function in a human model. However, the impact of environmental temperature, independent of exercise, has not been addressed in a human model. Thus, the purpose of this study was to compare the effects of exposure to hot, cold, and room temperature conditions on skeletal muscle gene expression related to mitochondrial biogenesis and muscle mass. Recreationally trained male subjects (n = 12) had muscle biopsies taken from the vastus lateralis before and after 3 h of exposure to hot (33 °C), cold (7 °C), or room temperature (20 °C) conditions. Temperature had no effect on most of the genes related to mitochondrial biogenesis, myogenesis, or proteolysis (p > 0.05). Core temperature was significantly higher in hot and cold environments compared with room temperature (37.2 ± 0.1 °C, p = 0.001; 37.1 ± 0.1 °C, p = 0.013; 36.9 ± 0.1 °C, respectively). Whole-body oxygen consumption was also significantly higher in hot and cold compared with room temperature (0.38 ± 0.01 L·min -1 , p < 0.001; 0.52 ± 0.03 L·min -1 , p < 0.001; 0.35 ± 0.01 L·min -1 , respectively). In conclusion, these data show that acute temperature exposure alone does not elicit significant changes in skeletal muscle gene expression. When considered in conjunction with previous research, exercise appears to be a necessary component to observe gene expression alterations between different environmental temperatures in humans.
Databáze: MEDLINE
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