Acute and Late Bartonella henselae Murine Model Infection.

Autor: da Silva MN; 1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil ., Vieira-Damiani G; 1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil .; 2 Federal Institute of Education , Science and Technology, São Paulo, Brazil ., Ericson ME; 3 Department of Dermatology, University of Minnesota Medical School , Minneapolis, Minnesota., Gupta K; 4 Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical School , Minneapolis, Minnesota., de Almeida AR; 1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil ., Drummond MR; 1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil ., Soares TC; 1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil ., Lania BG; 1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil ., Gilioli R; 5 Laboratory of Animal Quality Control, Multidisciplinary Center of Biological Investigation (CEMIB), University of Campinas (UNICAMP) , Campinas, Brazil ., Velho PE; 1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil .
Jazyk: angličtina
Zdroj: Vector borne and zoonotic diseases (Larchmont, N.Y.) [Vector Borne Zoonotic Dis] 2017 Mar; Vol. 17 (3), pp. 206-208. Date of Electronic Publication: 2017 Feb 06.
DOI: 10.1089/vbz.2016.2007
Abstrakt: Bartonella spp. are fastidious gram-negative neglected bacilli with worldwide distribution. They are able to cause intraerythrocytic and potentially fatal infection. Cats and dogs are reservoirs of some species of these agents. Blood-sucking arthropods are potential vectors. Our aim was to evaluate the blood, skin, liver, and spleen in BALB/c mice by using molecular tests and confocal microscopy to demonstrate Bartonella henselae infection in the bloodstream and organs after 4 and 21 days of intraperitoneally injected bacterial suspension. We demonstrate that the occurrence of infection in organs precedes the detectable infection in blood. Therefore, late manifestation in blood may be another challenge in early detection and diagnosis of B. henselae infection.
Databáze: MEDLINE