Fact or fiction: updates on how protein-coding genes might emerge de novo from previously non-coding DNA.

Autor:	Schmitz JF; Institute for Evolution and Biodiversity, University of Muenster, Muenster, Germany., Bornberg-Bauer E; Institute for Evolution and Biodiversity, University of Muenster, Muenster, Germany.
Jazyk:	angličtina
Zdroj:	F1000Research [F1000Res] 2017 Jan 19; Vol. 6, pp. 57. Date of Electronic Publication: 2017 Jan 19 (Print Publication: 2017).
DOI:	10.12688/f1000research.10079.1
Abstrakt:	Over the last few years, there has been an increasing amount of evidence for the de novo emergence of protein-coding genes, i.e. out of non-coding DNA. Here, we review the current literature and summarize the state of the field. We focus specifically on open questions and challenges in the study of de novo protein-coding genes such as the identification and verification of de novo -emerged genes. The greatest obstacle to date is the lack of high-quality genomic data with very short divergence times which could help precisely pin down the location of origin of a de novo gene. We conclude that, while there is plenty of evidence from a genetics perspective, there is a lack of functional studies of bona fide de novo genes and almost no knowledge about protein structures and how they come about during the emergence of de novo protein-coding genes. We suggest that future studies should concentrate on the functional and structural characterization of de novo protein-coding genes as well as the detailed study of the emergence of functional de novo protein-coding genes. Competing Interests: The authors declare that they have no competing interests. No competing interests were disclosed. No competing interests were disclosed. No competing interests were disclosed.
Databáze:	MEDLINE
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