High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform.
| Autor: | Nierode GJ; Chemical and Biological Engineering and Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA., Perea BC; Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720, USA., McFarland SK; Bioengineering, University of California, Berkeley, CA 94720, USA., Pascoal JF; Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisbon 1049-001, Portugal., Clark DS; Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720, USA., Schaffer DV; Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720, USA; Bioengineering, University of California, Berkeley, CA 94720, USA., Dordick JS; Chemical and Biological Engineering and Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. Electronic address: dordick@rpi.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Stem cell reports [Stem Cell Reports] 2016 Nov 08; Vol. 7 (5), pp. 970-982. Date of Electronic Publication: 2016 Oct 27. |
| DOI: | 10.1016/j.stemcr.2016.10.001 |
| Abstrakt: | A 3D cell culture chip was used for high-throughput screening of a human neural progenitor cell line. The differential toxicity of 24 compounds was determined on undifferentiated and differentiating NPCs. Five compounds led to significant differences in IC (Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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