| Autor: |
Lima FM; Center for Experimental Surgery, Department of Surgery, Center for Health Sciences, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil., Pinto FC; Center for Experimental Surgery, Department of Surgery, Center for Health Sciences, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil. fcmorone@gmail.com., Andrade-da-Costa BL; Department of Physiology and Pharmacology, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Silva JG; Immunopathology Laboratory Keizo Asami, LIKA, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil., Campos Júnior O; Immunopathology Laboratory Keizo Asami, LIKA, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil., Aguiar JL; Center for Experimental Surgery, Department of Surgery, Center for Health Sciences, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil. |
| Abstrakt: |
Duraplasty is necessary in nearly 30% of all neurological surgeries. Different tissues and materials have been evaluated in dura mater repair or as dural substitutes in neurosurgery. The aim was to evaluate the biocompatibility of the bacterial cellulose (BC) membranes, produced from sugarcane molasses, for dural defect repair in rats. Forty adults males Wistar rats divided into two groups: a control (ePTFE) and an experimental (BC). Bilateral frontoparietal craniectomy was performed, and a dural defect was created. The arachnoid underlying defect was disrupted with a narrow hook. The animals were observed for 120 days. There were no cases of infection, cerebrospinal fluid fistulae, delayed hemorrhages, behavior disturbances, seizures and palsies. The BC membrane showed to have suitable biocompatibility properties, was not induced immune reaction, nor chronic inflammatory response and absence of neurotoxicity signals. |
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