Cannabis use, COMT, BDNF and age at first-episode psychosis.

Autor: Mané A; Hospital del Mar, Medical Research Institute (IMIM), Department of Neurosciences and Psychiatry, Barcelona, Spain; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain. Electronic address: manesantacana@yahoo.es., Bergé D; Hospital del Mar, Medical Research Institute (IMIM), Department of Neurosciences and Psychiatry, Barcelona, Spain; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain., Penzol MJ; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain; Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain., Parellada M; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain; Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain; School of Medicine, Universidad Complutense, Madrid, Spain., Bioque M; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain; Barcelona Clinic Schizophrenia Unit, Hospital Clinic Barcelona, Spain., Lobo A; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain; Department of Psychiatry, Zaragoza University: IIS Aragón, Zaragoza, Spain., González-Pinto A; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain; Department of Psychiatry, University Hospital of Alava-Santiago, University of the Basque Country, Vitoria, Spain., Corripio I; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Cabrera B; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain; Barcelona Clinic Schizophrenia Unit, Hospital Clinic Barcelona, Spain., Sánchez-Torres AM; Department of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain., Saiz-Ruiz J; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain; IRYCIS, Department of Psychiatry, Hospital Ramon y Cajal, Universidad de Alcala, Madrid, Spain., Bernardo M; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain; Barcelona Clinic Schizophrenia Unit, Hospital Clinic Barcelona, Spain.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2017 Apr; Vol. 250, pp. 38-43. Date of Electronic Publication: 2017 Jan 19.
DOI: 10.1016/j.psychres.2017.01.045
Abstrakt: Although an interaction between COMT Val158Met and BDNF Val66Met polymorphisms with cannabis use has been proposed with respect to the risk of psychosis emergence, findings remain inconclusive. The aim of the present study was to evaluate the different possible associations between these polymorphisms and early cannabis use and the age at the first episode of psychosis. The relationship between age at psychosis onset and COMT Val158Met and BDNF Val66Met polymorphisms with early cannabis use as well as those factors associated with early cannabis use were investigated. Among 260 Caucasian first-episode psychosis patients, early cannabis use and the presence of the met-allele from the BDNF Val66Met polymorphism were significantly associated with age at psychosis onset. Furthermore, early cannabis use was significantly associated with male gender in the logistic regression analysis. These findings provide evidence of the important role of early cannabis use and the Val66Met BDNF polymorphism on age at psychosis onset and they point out to sex-specific differences in cannabis use patterns.
(Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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