In vitro protective effects of botryosphaeran, a (1→3;1→6)-β-d-glucan, against mutagens in normal and tumor rodent cells.

Autor: Kerche-Silva LE; Departamento de Bioquímica e Biotecnologia, Centro de Ciências Exatas - Universidade Estadual de Londrina, CEP 86.057-970, Londrina, PR, Brazil. Electronic address: leakerche@gmail.com., Cólus IM; Departamento de Biologia Geral, Centro de Ciências Biológicas - Universidade Estadual de Londrina, CEP 86.057-970, Londrina, PR, Brazil. Electronic address: ilcecolus@gmail.com., Malini M; Departamento de Biologia Geral, Centro de Ciências Biológicas - Universidade Estadual de Londrina, CEP 86.057-970, Londrina, PR, Brazil. Electronic address: maressa.malini@gmail.com., Mori MP; Departamento de Biologia Geral, Centro de Ciências Biológicas - Universidade Estadual de Londrina, CEP 86.057-970, Londrina, PR, Brazil. Electronic address: mori_mateus@yahoo.com.br., Dekker RF; Programa de Pós-Graduação em Engenharia Ambiental, Universidade Tecnológica Federal do Paraná, Câmpus Londrina, CEP 86.036-370, Londrina, PR, Brazil. Electronic address: xylanase@gmail.com., Barbosa-Dekker AM; Departamento de Bioquímica e Biotecnologia, Centro de Ciências Exatas - Universidade Estadual de Londrina, CEP 86.057-970, Londrina, PR, Brazil. Electronic address: anelibarbosa@gmail.com.
Jazyk: angličtina
Zdroj: Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2017 Feb; Vol. 814, pp. 29-36. Date of Electronic Publication: 2016 Dec 31.
DOI: 10.1016/j.mrgentox.2016.12.003
Abstrakt: Botryosphaeran (BOT) is an exocellular β-d-glucan (carbohydrate biopolymer) of the (1→3;1→6)-linked type produced by Botryosphaeria rhodina MAMB-05. The cytotoxic, mutagenic, genotoxic, and protective effects of this substance were evaluated in Chinese hamster lung fibroblasts (V79) and rat hepatocarcinoma cells (HTC) by the micronucleus test (MN) and the comet assay. BOT was not genotoxic in either cell line; it decreased the clastogenic effects of doxorubicin, H 2 O 2 , and benzo[a]pyrene. These results indicate that BOT may have potential as a therapeutic agent.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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