Functionally relevant proteins in Plasmodium falciparum host cell invasion.

Autor:	Patarroyo ME; Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20 Bogotá, Colombia.; Universidad Nacional de Colombia, Bogotá DC, Colombia., Alba MP; Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20 Bogotá, Colombia.; Universidad de Ciencias Aplicadas y Ambientales (UDCA), Bogotá, Colombia., Rojas-Luna R; Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20 Bogotá, Colombia., Bermudez A; Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20 Bogotá, Colombia.; Universidad del Rosario, Bogotá DC, Colombia., Aza-Conde J; Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20 Bogotá, Colombia.
Jazyk:	angličtina
Zdroj:	Immunotherapy [Immunotherapy] 2017 Jan; Vol. 9 (2), pp. 131-155.
DOI:	10.2217/imt-2016-0091
Abstrakt:	A totally effective, antimalarial vaccine must involve sporozoite and merozoite proteins (or their fragments) to ensure complete parasite blocking during critical invasion stages. This Special Report examines proteins involved in critical biological functions for parasite survival and highlights the conserved amino acid sequences of the most important proteins involved in sporozoite invasion of hepatocytes and merozoite invasion of red blood cells. Conserved high activity binding peptides are located in such proteins' functionally strategic sites, whose functions are related to receptor binding, nutrient and protein transport, enzyme activity and molecule-molecule interactions. They are thus excellent targets for vaccine development as they block proteins binding function involved in invasion and also their biological function.
Databáze:	MEDLINE
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