Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value.

Autor: Sadeghi-Hokmabadi E; Department of Neurology, Neurocritical Care, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, Turkey., Baş DF; Department of Neurology, Neurocritical Care, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, Turkey., Farhoudi M; Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran., Taheraghdam A; Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran., Savadi Oskouei D; Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran., Yazdchi M; Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran., Hashemilar M; Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran., Uzuner N; Department of Neurology, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, Turkey., Mirnour R; Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran., Colak E; Department of Biostatistics, Eskisehir Osmangazi University, Eskisehir, Turkey., Özdemir AÖ; Department of Neurology, Neurocritical Care, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, Turkey.
Jazyk: angličtina
Zdroj: Stroke research and treatment [Stroke Res Treat] 2017; Vol. 2017, pp. 2371956. Date of Electronic Publication: 2017 Jan 03.
DOI: 10.1155/2017/2371956
Abstrakt: Objective . This study was set to assess the effect of renal dysfunction on outcome of stroke patients treated with intravenous thrombolysis (IVT). Methods . This multicenter research involved 403 patients from January 2009 to March 2015. Patients were divided into two groups: (1) control group with GFR ≥ 45 mL/min/1.73 m 2 and (2) low GFR group with GFR < 45 mL/min/1.73 m 2 . Outcome measurements were poor outcome (mRS 3-6) and mortality at 3 months and symptomatic intracerebral hemorrhage (SICH) within the first 24-36 hours. Univariate and multivariate regression analyses were performed, and odds ratios (ORs) were determined at 95% confidence intervals (CIs). Results . Univariate analyses determined that every decrease of GFR by 10 mL/min/1.73 m 2 significantly increased the risk of poor outcome (OR 1.19, 95% CI 1.09-1.30, p < 0.001) and mortality (OR 1.18, 95% CI 1.06-1.32, p = 0.002). In multivariate regression, adjusted for all variables with p value < 0.1, low GFR (GFR < 45 versus GFR equal to or more than 45) was associated with poor outcome (OR adjusted 2.15, 95% CI 1.01-4.56, p = 0.045). Conclusion . In IVT for acute stroke, renal dysfunction with GFR < 45 mL/min/1.73 m 2 before treatment determined increased odds for poor outcome compared to GFR of more than 45 mL/min/1.73 m 2 .
Competing Interests: The authors declare that there is no conflict of interests regarding the publication of this paper.
Databáze: MEDLINE
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