Intermediate analysis of magnesium alloy covered stent for a lateral aneurysm model in the rabbit common carotid artery.

Autor: Cui HK; Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China.; No.88, Jian Kang Road, Weihui, 453100, Henan Province, China., Li FB; Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China.; No.88, Jian Kang Road, Weihui, 453100, Henan Province, China., Guo YC; Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China.; No.88, Jian Kang Road, Weihui, 453100, Henan Province, China., Zhao YL; Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China.; No.88, Jian Kang Road, Weihui, 453100, Henan Province, China., Yan RF; Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China.; No.88, Jian Kang Road, Weihui, 453100, Henan Province, China., Wang W; Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, (Fengxian Hospital), Shanghai, 200233, China.; No. 600, Yi Shan Road, Shanghai, 200233, China., Li YD; Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China. dr_liyongdong@sina.com.; No.88, Jian Kang Road, Weihui, 453100, Henan Province, China. dr_liyongdong@sina.com.; Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, (Fengxian Hospital), Shanghai, 200233, China. dr_liyongdong@sina.com.; No. 600, Yi Shan Road, Shanghai, 200233, China. dr_liyongdong@sina.com., Wang YL; Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, (Fengxian Hospital), Shanghai, 200233, China. yongliwang2008@163.com.; No. 6600, Nan Feng Road, Shanghai, 210499, China. yongliwang2008@163.com., Yuan GY; National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai, 200240, China. gyyuan@sjtu.edu.cn.; No. 800, Dong Chuan Road, Shanghai, 200240, China. gyyuan@sjtu.edu.cn.
Jazyk: angličtina
Zdroj: European radiology [Eur Radiol] 2017 Sep; Vol. 27 (9), pp. 3694-3702. Date of Electronic Publication: 2017 Jan 26.
DOI: 10.1007/s00330-016-4715-6
Abstrakt: Objective: To analyze the outcomes of a magnesium alloy covered stent (MACS) for a lateral aneurysm model in common carotid artery (CCA).
Methods: In 32 rabbits, a MACS (group A, n = 17) or a Willis covered stent (WCS; group B, n = 15) was inserted and the rabbits were sacrificed 1, 3, 6, or 12 months after stenting. Angiography and intravascular ultrasound (IVUS) were performed at 3, 6, and 12 months. Scanning electron microscopy was performed for six stents in each group at 1, 3, and 6 months, and histopathology and histomorphology were conducted at 3 (n = 4), 6 (n = 4), and 12 (n = 12) months.
Results: Final angiography showed complete occlusion of the aneurysms in 12 cases. IVUS at 6 and 12 months revealed a significant increase in mean lumen area of the stented CCA in group A and also showed greater mean lumen area in group A than in group B. The endothelialization process was quicker in group A than in group B.
Conclusion: MACS is effective for occlusion of lateral aneurysms and is superior to WCS in growth of the stented CCA and endothelialization. Further work is needed to make this device available for human use.
Key Points: • The MACS is an effective approach for occlusion of a lateral aneurysm. • IVUS showed that the CCA could grow following degradation of the MACS. • The lumen area of the stented CCA was excellent in MACS. • HE staining displayed the degradation of the magnesium alloy stent. • Combination of IVUS and DSA were applied in this study.
Databáze: MEDLINE
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