| Autor: |
Woelfle R; Department of Cell and Systems Biology, University of Toronto, Toronto, Canada., D'Aquila AL; Department of Cell and Systems Biology, University of Toronto, Toronto, Canada., Lovejoy DA; Department of Cell and Systems Biology, University of Toronto, Toronto, Canada. |
| Jazyk: |
angličtina |
| Zdroj: |
Translational neuroscience [Transl Neurosci] 2016 Feb 24; Vol. 7 (1), pp. 17-23. Date of Electronic Publication: 2016 Feb 24 (Print Publication: 2016). |
| DOI: |
10.1515/tnsci-2016-0004 |
| Abstrakt: |
Mood disorders, including anxiety and depression, are thought to be characterized by disrupted neuronal synapses and altered brain plasticity. The etiology is complex, involving numerous regions of the brain, comprising a multitude of neurotransmitter and neuromodulator systems. Recently, new studies on the teneurins, an evolutionary ancient family of type II transmembrane proteins have been shown to interact with latrophilins (LPHN), a similarly phylogenetically old family of adhesion G protein-coupled receptors (GPCR) forming a transsynaptic adhesion and ligand-receptor pair. Each of the four teneurin proteins contains bioactive sequences termed the teneurin C-terminal associated peptides (TCAP-1-4), which possess a number of neuromodulatory effects. The primary structures of the TCAP are most closely similar to the corticotropin-releasing factor (CRF) family of peptides. CRF has been implicated in a number of diverse mood disorders. Via an association with dystroglycans, synthetic TCAP-1 administration to both embryonic and primary hippocampal cultures induces long-term changes in neuronal structure, specifically increased neurite outgrowth, dendritic branching, and axon growth. Rodent models treated with TCAP-1 show reduced anxiety responses in the elevated plus-maze, openfield test, and acoustic startle test and inhibited CRF-mediated cocaine-seeking behaviour. Thus the teneurin/TCAP-latrophilin interaction may play a major role in the origin, development and treatment of mood disorders. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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