Coordinated Acetylcholine Release in Prefrontal Cortex and Hippocampus Is Associated with Arousal and Reward on Distinct Timescales.

Autor:	Teles-Grilo Ruivo LM; Lilly Centre for Cognitive Neuroscience, Eli Lilly and Company Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK., Baker KL; Department of Chemistry, Maynooth University, Co. Kildare, Ireland., Conway MW; Lilly Centre for Cognitive Neuroscience, Eli Lilly and Company Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK., Kinsley PJ; Lilly Centre for Cognitive Neuroscience, Eli Lilly and Company Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK., Gilmour G; Lilly Centre for Cognitive Neuroscience, Eli Lilly and Company Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK., Phillips KG; Lilly Centre for Cognitive Neuroscience, Eli Lilly and Company Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK., Isaac JTR; Lilly Centre for Cognitive Neuroscience, Eli Lilly and Company Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK., Lowry JP; Department of Chemistry, Maynooth University, Co. Kildare, Ireland. Electronic address: john.lowry@nuim.ie., Mellor JR; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK. Electronic address: jack.mellor@bristol.ac.uk.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2017 Jan 24; Vol. 18 (4), pp. 905-917.
DOI:	10.1016/j.celrep.2016.12.085
Abstrakt:	Cholinergic neurotransmission throughout the neocortex and hippocampus regulates arousal, learning, and attention. However, owing to the poorly characterized timing and location of acetylcholine release, its detailed behavioral functions remain unclear. Using electrochemical biosensors chronically implanted in mice, we made continuous measurements of the spatiotemporal dynamics of acetylcholine release across multiple behavioral states. We found that tonic levels of acetylcholine release were coordinated between the prefrontal cortex and hippocampus and maximal during training on a rewarded working memory task. Tonic release also increased during REM sleep but was contingent on subsequent wakefulness. In contrast, coordinated phasic acetylcholine release occurred only during the memory task and was strongly localized to reward delivery areas without being contingent on trial outcome. These results show that coordinated acetylcholine release between the prefrontal cortex and hippocampus is associated with reward and arousal on distinct timescales, providing dual mechanisms to support learned behavior acquisition during cognitive task performance. (Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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