BrachyView: Combining LDR seed positions with transrectal ultrasound imaging in a prostate gel phantom.

Autor: Alnaghy S; Centre for Medical Radiation Physics, University of Wollongong, Australia. Electronic address: anatoly@uow.edu.au., Cutajar DL; Centre for Medical Radiation Physics, University of Wollongong, Australia., Bucci JA; St George Cancer Care Centre, St George Hospital, Kogarah, New South Wales, Australia., Enari K; Advanced Computer System Pty Ltd, Rome, Italy., Safavi-Naeini M; Centre for Medical Radiation Physics, University of Wollongong, Australia., Favoino M; Advanced Computer System Pty Ltd, Rome, Italy., Tartaglia M; Advanced Computer System Pty Ltd, Rome, Italy., Carriero F; Advanced Computer System Pty Ltd, Rome, Italy., Jakubek J; Institute of Experimental and Applied Physics, Czech Technical University of Prague, Prague, Czech Republic., Pospisil S; Institute of Experimental and Applied Physics, Czech Technical University of Prague, Prague, Czech Republic., Lerch M; Centre for Medical Radiation Physics, University of Wollongong, Australia., Rosenfeld AB; Centre for Medical Radiation Physics, University of Wollongong, Australia., Petasecca M; Centre for Medical Radiation Physics, University of Wollongong, Australia. Electronic address: marcop@uow.edu.au.
Jazyk: angličtina
Zdroj: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [Phys Med] 2017 Feb; Vol. 34, pp. 55-64. Date of Electronic Publication: 2017 Jan 22.
DOI: 10.1016/j.ejmp.2017.01.012
Abstrakt: Purpose: BrachyView is a novel in-body imaging system which aims to provide LDR brachytherapy seeds position reconstruction within the prostate in real-time. The first prototype is presented in this study: the probe consists of a gamma camera featuring three single cone pinhole collimators embedded in a tungsten tube, above three, high resolution pixelated detectors (Timepix).
Methods: The prostate was imaged with a TRUS system using a sagittal crystal with a 2.5mm slice thickness. Eleven needles containing a total of thirty 0.508U 125 I seeds were implanted under ultrasound guidance. A CT scan was used to localise the seed positions, as well as provide a reference when performing the image co-registration between the BrachyView coordinate system and the TRUS coordinate system. An in-house visualisation software interface was developed to provide a quantitative 3D reconstructed prostate based on the TRUS images and co-registered with the LDR seeds in situ. A rigid body image registration was performed between the BrachyView and TRUS systems, with the BrachyView and CT-derived source locations compared.
Results: The reconstructed seed positions determined by the BrachyView probe showed a maximum discrepancy of 1.78mm, with 75% of the seeds reconstructed within 1mm of their nominal location. An accurate co-registration between the BrachyView and TRUS coordinate system was established.
Conclusions: The BrachyView system has shown its ability to reconstruct all implanted LDR seeds within a tissue equivalent prostate gel phantom, providing both anatomical and seed position information in a single interface.
(Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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